Genes and polypeptides relating to hepatocellular or...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/12 (2006.01) A61K 31/7088 (2006.01) A61K 31/7105 (2006.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07H 21/00 (2006.01) C07K 14/47 (2006.01) C07K 14/82 (2006.01) C12N 15/11 (2006.01) C12P 21/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2488621

The present application provides novel human genes WDRPUH and KRZFPUH, and PPIL1 whose expression is markedly elevated in a great majority of HCCs and colorectal cancers, respectively, compared to corresponding non-cancerous tissues, as well as novel human gene APCDD1 whose expression is elevated in primary colon cancers and down-regulated in response to the transduction of wild-type APC1 into colon-cancer cells. The genes and polypeptides encoded by the genes can be used, for example, in the diagnosis of a cell proliferative disease, and as target molecules for developing drugs against the disease.

La présente invention concerne des gènes humains WDRPUH et KRZFPUH, et PPIL1, dont l'expression est manifestement élevée dans une grande majorité de carcinomes hépatocellulaires et de cancers colorectaux, respectivement, en comparaison avec des tissus non cancéreux correspondants. Cette invention a aussi trait au gène humain APCDD1, dont l'expression est élevée dans des cancers du côlon primaires et régulée et abaissée, en réponse à la transduction d'APC1 de type sauvage dans des cellules du cancer du côlon. Les gènes et les polypeptides codés par les gènes peuvent être utilisés, par exemple, dans le diagnostic d'un maladie de prolifération cellulaire, et en tant que molécules cibles destinées à développer des médicaments contre la maladie.

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