Diagnosis, prevention and treatment of ulcerative colitis,...

A - Human Necessities – 61 – K

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A61K 39/00 (2006.01) A61K 38/17 (2006.01) A61K 39/02 (2006.01) A61K 39/385 (2006.01) C07K 14/245 (2006.01) C07K 16/12 (2006.01) C07K 16/18 (2006.01) C12Q 1/18 (2006.01) G01N 33/564 (2006.01) G01N 33/569 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2322763

The present invention relates to microbial UC pANCA antigens. The invention provides methods of diagnosing ulcerative colitis (UC) and methods of inducing tolerance in a pANCA-positive patient with UC using a histone H1-like antigen. The invention further provides methods of diagnosing UC and methods of inducing tolerance in a pANCA-positive patient with UC using a porin antigen. Methods of diagnosing UC and methods of inducing tolerance in a pANCA-positive patient with UC using a Bacteroids antigen are also provided.

La présente invention se rapporte à des antigènes microbiens produisant des anticorps UC pANCA. Elle se rapporte notamment à des méthodes de diagnostic de la recto-colite hémorragique (UC ulcerative colitis) et à des procédés permettant d'induire une tolérance chez un patient atteint de recto-colite hémorragique et positif aux pANCA à l'aide d'un antigène semblable à l'histone H1. L'invention se rapporte en outre à des méthodes de diagnostic de la recto-colite hémorragique et à des méthodes permettant d'induire une tolérance chez un patient atteint de recto-colite hémorragique et positif aux pANCA à l'aide d'un antigène de type porine. Enfin, l'invention se rapporte à des méthodes de diagnostic de la recto-colite hémorragique et à des méthodes permettant d'induire une tolérance chez un patient atteint de recto-colite hémorragique et positif aux pANCA à l'aide d'un antigène du genre Bacteroides.

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