Peptide pharmaceuticals for nasal delivery

A - Human Necessities – 61 – K

Patent

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Details

A61K 47/26 (2006.01) A61K 38/29 (2006.01) A61K 47/12 (2006.01)

Patent

CA 2754593

Pharmaceutical products for nasal administration contain peptide active agents and are formulated with compounds that enhance bioavailability of the peptide active agents. In particular, citrates, fatty acids, sugar esters of fatty acids or acyl carnitines are used. In some embodiments, a sugar ester of a fatty acid is used in combination with either a fatty acid, or alternatively, an acyl carnitine.

L'invention porte sur des produits pharmaceutiques pour administration nasale, contenant des agents actifs peptidiques et formulés avec des composés qui améliorent la biodisponibilité des agents peptidiques actifs. On utilise en particulier des citrates, des acides gras, de l'ester de sucre d'acide gras ou de la carnitine d'alcyle. Dans certains modes de réalisation, on utilise un ester de sucre d'un acide gras en combinaison soit avec un acide gras, soit en variante avec une carnitine d'alcyle.

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