Novel inhibitors of glutaminyl cyclase

Details Novel inhibitors of glutaminyl cyclase Novel inhibitors of glutaminyl cyclase

C - Chemistry, Metallurgy

07

D

C07D 233/61 (2006.01) A61K 31/4164 (2006.01) A61K 38/06 (2006.01) A61P 25/14 (2006.01) A61P 25/28 (2006.01) C07D 235/06 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2554809

The present invention relates to novel inhibitors of glutaminyl cyclase and combinations thereof for the treatment of neuronal disorders, especially Alzheimer~s disease, Down Syndrome, Parkinson disease, Chorea Huntington, pathogenic psychotic conditions, schizophrenia, impaired food intake, sleep- wakefulness, impaired homeostatic regulation of energy metabolism, impaired autonomic function, impaired hormonal balance, impaired regulation, body fluids, hypertension, fever, sleep dysregulation, anorexia, anxiety related disorders including depression, seizures including epilepsy, drug withdrawal and alcoholism, neurodegenerative disorders including cognitive dysfunction and dementia.

La présente invention concerne de nouveaux inhibiteurs de la glutaminyl-cyclase et des combinaisons de ces derniers pour traiter les troubles neuronaux, notamment la maladie d'Alzheimer, le syndrome de Down, la maladie de Parkinson, la chorée de Huntington, les états psychotiques pathogènes, la schizophrénie, les apports alimentaires insuffisants, l'insomnie, l'altération de la régulation homéostatique du métabolisme énergétique, la dystonie neurovégétative, l'altération de l'équilibre hormonal, l'altération de la régulation, les liquides organiques, l'hypertension, la fièvre, la dysrégulation du sommeil, l'anorexie, les troubles liés à l'anxiété tels que la dépression, les crises notamment l'épilepsie, le sevrage de drogues et l'alcoolisme, les troubles neurodégénératifs notamment le dysfonctionnement cognitif et la démence.

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