C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 311/46 (2006.01) A61K 31/27 (2006.01) A61K 31/33 (2006.01) C07D 207/26 (2006.01) C07D 207/27 (2006.01) C07D 209/08 (2006.01) C07D 213/30 (2006.01) C07D 215/48 (2006.01) C07D 231/14 (2006.01) C07D 239/22 (2006.01) C07D 263/24 (2006.01) C07D 271/08 (2006.01) C07D 271/12 (2006.01) C07D 277/36 (2006.01) C07D 307/12 (2006.01) C07D 307/20 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 407/12 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417
Patent
CA 2143208
The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors, of formula (I). In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The com- pounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting HIV-1 and HIV-2 protease activity and consequently, may be advantageously used as antiviral agents against the HIV-1 and HIV-2 viruses. This invention also relates to methods for inhibiting the activity of HIV aspartyl protease using the compounds of this invention and methods for screening compounds for anti-HIV activity.
Bhisetti Govinda R.
Murcko Mark A.
Tung Roger D.
Smart & Biggar
Vertex Pharmaceuticals Incorporated
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