Inhibition of cell death responses induced by oxidative stress

Details Inhibition of cell death responses induced by oxidative stress Inhibition of cell death responses induced by oxidative stress

A - Human Necessities

61

K

A61K 31/505 (2006.01) A61K 31/513 (2006.01)

Patent

CA 2479257

The invention provides methods of reducing or preventing oxidative stress- induced cell death by contacting a cell with a compound that inhibits the kinase activity and/or the mitochondrial translocation of c-Abl. The methods of the invention can be used to treat individuals individual diagnosed as having or being at risk of contracting a disorder characterized by excessive oxidative stress-induced cell death.

L'invention concerne des méthodes de réduction ou de prévention de mort cellulaire induite par stress oxydatif, consistant à mettre une cellule en contact avec un composé inhibant l'activité kinase et/ou la translocation mitochondriale de c-Abl. Les méthodes de l'invention peuvent être utilisées pour traiter des individus chez qui on a diagnostiqué un trouble caractérisé par une mort cellulaire induite par un stress oxydatif excessif ou présentant un risque de contracter un tel trouble.

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