Somatostatin agonists

Details Somatostatin agonists Somatostatin agonists

C - Chemistry, Metallurgy

07

D

C07D 403/14 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01)

Patent

CA 2285223

Somatostatin agonist compounds of formula (I) are disclosed, including pharmaceutically acceptable salts and hydrates thereof. These compounds are useful in the treatment of diabetes, cancer, acromegaly, restenosis, depression, irritable bowel syndrome and pain. The compounds are potent with high selectivity toward the receptor subtype (2). Pharmaceutical compositions and methods of treatment are also included.

L'invention concerne des agonistes de somatostatine de formule (I), y compris leurs sels et hydrates pharmaceutiquement acceptables . Ces composés sont utiles dans le traitement du diabète, du cancer, de l'acromégalie, de la resténose, de la dépression, du côlon irritable et de la douleur. Ces composés sont puissants et présentent un sélectivité importante en faveur du sous-type 2 des récepteurs. L'invention porte également sur des compositions pharmaceutiques et des méthodes de traitement.

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