Vaccines for oral immunization against infecting agents

Details Vaccines for oral immunization against infecting agents Vaccines for oral immunization against infecting agents

A - Human Necessities

61

K

A61K 39/385 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2189469

The invention relates to conjugates of an antigenic material selected from the group of a toxin, or a fragment thereof, a toxoid and/or an adherence antigen derived from an infecting agent, wherein said antigenic material is covalently bound to a physiologically acceptable inert carrier, such as silica, chemically-modified silica, aluminium silicate, kaolin or latex. The conjugates are for use in vaccines for oral immunization against infecting agents, e.g., gastrointestinal microbial infections such as cholera,

Conjugués d'un matériau antigénique choisi dans le groupe comprenant une toxine ou un fragment de celle-ci, un toxoïde et/ou un antigène d'adhérence dérivé d'un agent d'infection, dans lesquels ledit matériau antigénique étant lié de manière covalente à un excipient inerte acceptable sur le plan physiologique tel que de la silice, de la silice modifiée chimiquement, du silicate d'aluminium, du kaolin ou du latex. Ces conjugués sont utiles dans des vaccins destinés à l'immunisation par voie orale contre des agents d'infection, par exemple les agents provoquant une infection microbienne gastro-intestinale telle que le choléra.

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