Tnf- .alpha. inhibitors

Details Tnf- .alpha. inhibitors Tnf- .alpha. inhibitors

A - Human Necessities

61

K

A61K 31/22 (2006.01) A61K 31/366 (2006.01) A61K 31/40 (2006.01) A61K 31/405 (2006.01) A61K 31/4409 (2006.01) A61K 31/4418 (2006.01) A61K 31/4709 (2006.01) A61K 31/505 (2006.01) A61P 9/04 (2006.01) A61P 9/10 (2006.01) A61P 11/00 (2006.01) A61P 11/06 (2006.01) A61P 13/10 (2006.01) A61P 13/12 (2006.01) A61P 19/02 (2006.01) A61P 25/16 (2006.01) A61P 25/28 (2006.01) A61P 29/00 (2006.01) A61P 31/04 (2006.01) A61P 31/12 (2006.01) A61P 37/02 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2399396

TNF- inhibitors containing at least one compound selected from among serivastatin, atorvastatin, simvastatin, pravastatin, itavastatin and (+)- (3R,5S)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N- methanesulfonylamino)pyrimidin-5-yl]-3,5-dihydroxy-6(E)-heptenoic acid and salts thereof which have sufficiently favorable properties as drugs, for example, exhibiting excellent preventive and therapeutic effects on TNF- .alpha.-associated diseases such as inflammatory diseases without showing any side effects.

L'invention concerne des inhibiteurs de TNF-.alpha. contenant au moins un composé sélectionné dans le groupe constitué par sérivastatine, atorvastatine, simvastatine, pravastatine, itavastatine et acide (+)-(3R, 5S)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-methanesulfonylamino)pyrimidin-5-yl]-3,5-dihydroxy-6(E)- heptonique et des sels de celui-ci, qui possèdent des propriétés permettant de les utiliser comme médicaments, par exemple, d'excellents effets thérapeutiques préventifs sur des maladies associées à TNF-.alpha., telles que des maladies inflammatoires, sans provoquer d'effets secondaires.

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