A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/00 (2006.01) A61K 31/4468 (2006.01) A61K 31/4515 (2006.01) A61K 31/519 (2006.01) A61K 31/554 (2006.01) A61P 25/18 (2006.01)
Patent
CA 2681506
Combinations of 5-HT2A inverse agonists or antagonists such as pimavanserin with antipsychotics such as risperidone are shown to induce a rapid onset of antipsychotic action and increase the number of responders when compared to therapy with the antipsychotic alone. These effects can be achieved at a low dose of the antipsychotic, thereby reducing the incidence of side effects. The combinations are also effective at decreases the incidence of weight gain and increased glucose or prolactin levels caused by the antipsychotic.
L'invention concerne des combinaisons d'agonistes ou antagonistes inverses de 5-HT2A tels que la pimavansérine avec des antipsychotiques tels que la rispéridone pour induire un départ rapide d'une action antipsychotique et augmenter le nombre de répondeurs en comparaison à une thérapie avec seulement l'antipsychotique. Ces effets peuvent être atteints à une faible dose de l'antipsychotique, réduisant ainsi l'incidence des effets secondaires. Les combinaisons sont également efficaces pour diminuer l'incidence de la prise de poids et des taux accrus de glucose ou de prolactine induits par l'antipsychotique.
Bahr Daun
Brann Mark
Furlano David
Peters Perry
Van Kammen Daniel
Acadia Pharmaceuticals Inc.
Osler Hoskin & Harcourt Llp
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