Purification process of montelukast and its amine salts

Details Purification process of montelukast and its amine salts Purification process of montelukast and its amine salts

C - Chemistry, Metallurgy

07

D

C07D 215/18 (2006.01) A61K 31/4704 (2006.01)

Patent

CA 2657775

It comprises a process for the purification of Montelukast, or its salts or its solvates, including any stereoisomer or mixture thereof, which comprises converting Montelukast acid or a solvate thereof, including any stereoisomer or mixtures thereof, into an amine salt selected from the group consisting of tris-(hydroxymethyl)aminomethane, L-(+)-treo-2-amino-1-phenyl-1,3- propanediol, and L-(+)-.alpha.-phenylglycinol salt, in the presence of an appropriate solvent. It also comprises novel salts of Montelukast, in particular, tris-(hydroxymethyl)aminomethane, L-(+)-treo-2-amino-1-phenyl-1,3- propanediol, and L-(+)-.alpha.-phenylglycinol salts.

L'invention concerne un procédé de purification du montélukast, ou de ses sels ou de ses solvats, y compris tout stéréoisomère ou mélange de celui-ci, qui comprend la conversion d'un acide de montélukast ou d'un solvat de celui-ci, y compris tout stéréoisomère ou les mélanges de celui-ci, en un sel d'amine choisi dans le groupe constitué par un sel de tris-(hydroxyméthyl)aminométhane, de L-(+)-tréo-2-amino-1-phényl-1,3- propanediol, et de L-(+)-.alpha.-phénylglycinol, en présence d'un solvant approprié. L'invention concerne également de nouveaux sels de montélukast, en particulier les sels de tris-(hydroxyméthyl)aminométhane, de L-(+)-tréo-2-amino-1-phényl-1,3- propanediol, et de L-(+)-.alpha.-phénylglycinol.

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