Heterocyclic cytotoxic agents

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 237/26 (2006.01) A61K 31/502 (2006.01) A61K 31/5025 (2006.01) A61P 35/00 (2006.01) C07D 221/00 (2006.01) C07D 237/00 (2006.01) C07D 317/00 (2006.01) C07D 471/04 (2006.01) C07D 471/14 (2006.01) C07D 487/04 (2006.01) C07D 491/04 (2006.01)

Patent

CA 2389312

The invention provides compounds of formula (I), wherein R1-R8 ang A-G have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also provides pharmaceutical compositions comprising a compound of formula (I), processes for preparing compounds of formula (I), intermediates useful for preparing compounds of formula (I), and therapeutic methods for treating cancer using compounds of formula (I).

L'invention concerne des composés de la formule (I) dans laquelle R¿1?-R¿8? et A-G ont n'importe laquelle des définitions décrites dans le mémorandum descriptif, et leurs sels pharmaceutiquement acceptables. L'invention concerne en outre des compositions pharmaceutiques comprenant un composé de la formule (I), des méthodes de préparation de composés de la formule (I), des intermédiaires utiles pour la préparation de composés de la formule (I), et des méthodes thérapeutiques pour le traitement du cancer utilisant des composés de la formule (I).

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