C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 15/00 (2006.01) A61K 31/40 (2006.01) A61K 31/555 (2006.01) A61K 41/00 (2006.01) A61P 31/00 (2006.01) A61P 33/00 (2006.01) C07D 487/22 (2006.01) C07D 491/22 (2006.01) C12P 17/18 (2006.01)
Patent
CA 2353554
Palladium-substituted Bacteriochlorophyll derivatives of formula (See formula I) wherein A represents OH, OR1, -O-(CH2)n-Y, -S-(CH2)n-Y, -NH-(CH2)n-Y, -O-(CH2)2-OH, or -N-(CH2-CH=CH2)2; wherein R1 represents Na+, K+, (Ca2+)0,5, (Mg2+)0,5, Li+, NH4, +NH3-C(CH2OH)3, +NH3-CH2-(CHOH)4-CH2OH, +NH2(CH3)-CH2- (CHOH)4-CH2OH or +N(C n'H2n'+1)4; R2 represents H, OH or COOR4 when the compound is of formula I, wherein R4 is C1-C12 alkyl or C3-C12 cycloalkyl, or R2 represents H or C1-C12 alkyl when the compound is of formula I'; R3 represents H, OH or C1-C12 alkyl or alkoxy when the compound is of formula I, or R3 represents H or C1-C12 alkyl when the compound is of formula I'; n is 1, 2, 3, 4, 5 or 6, Y is - NR'1R'2 or -+NR'1R'2R'3, X- wherein R'1, R'2 and R'3 independently from each other represent -CH3 or -C2H5; X is F, Cl, Br or I, n' is 1, 2, 3 or 4 and their oxidized forms, are useful in the field of photodynamic therapy (PDT).
L'invention concerne des dérivés bactériochlorophylle à substitution palladium, correspondant à la formule (I) dans laquelle A représente OH, OR¿1?,O-(CH¿2?)¿n?-Y,S-(CH¿2?)¿n?-Y,NH-(CH¿2?)¿n?-Y,O-(CH¿2?)¿2?-NH¿2?,O-(CH¿2?)¿2?-OH,NH-(CH¿2?)¿n?- ?+¿N o, X?-¿,NH-(CH¿2?)¿2?-NH=BOC ouN-(CH¿2?-CH=CH¿2?)¿2?, où R¿1? représente Na?+¿, K?+¿, (Ca?2+¿)¿0,5,? (Mg?2+¿)¿0,5?, Li?+¿, NH¿4??+¿, ?+¿NH¿3?-C(CH¿2?OH)¿3?, ?+¿NH¿3?-CH¿2?-(CHOH)¿4?-CH¿2?OH, ?+¿NH¿2?(CH¿3?)-CH¿2?-(CHOH)¿4?-CH¿2?OH or ?+¿N(C¿n'?H¿2n'+1?)¿4?, R¿2? représente H, OH or COOR¿4?, où R¿4? représente alkyle C¿1?-C¿12? ou cycloalkyle C¿3?-C¿12?, R¿3? représente H, OH ou alkyle ou alcoxy C¿1?-C¿12?; n vaut 1, 2, 3, 4, 5 ou 6, Y représenteNR'¿1?R'¿2? ou?+¿NR'¿1?R'¿2?R'¿3?, X?-¿ où R'¿1?, R'¿2? et R'¿3? représentent chacun indépendammentCH¿3? ouC¿2?H¿5?; X représente F, Cl, Br ou l, n' vaut 1, 2, 3 ou 4. L'invention concerne également des formes oxydées de ces dérivés. Ces dérivés et leurs formes oxydées sont utiles dans le domaine de la thérapie photodynamique (TPD).
Brandis Alexander
Salomon Yoram
Scheer Hugo
Scherz Avigdor
Borden Ladner Gervais Llp
Ltd. Yeda Research And Development Co.
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