Vaccine using papillomavirus e proteins delivered by viral...

Details Vaccine using papillomavirus e proteins delivered by viral... Vaccine using papillomavirus e proteins delivered by viral...

A - Human Necessities

61

K

A61K 39/12 (2006.01) C07H 21/04 (2006.01) C07K 14/025 (2006.01) C12N 7/00 (2006.01) C12N 15/00 (2006.01)

Patent

CA 2457890

Cell-mediated immune response to a papillomavirus infection can be induced by vaccination with DNA encoding papillomavirus E genes. E genes can both prevent the occurrence of papillomavirus disease, and treat disease states. Canine papillomavirus (COPV) E genes which are codon-optimized to enhance expression in host cells are also given.

Selon cette invention, une réponse immune à médiation cellulaire à une infection par le virus du papillome peut être provoquée au moyen d'une vaccination avec de l'ADN codant pour des gènes précoces (E) du virus du papillome. Ces gènes E permettent à la fois de prévenir l'apparition de la maladie du virus du papillome, et de traiter des états maladifs. L'invention concerne également des gènes E du virus du papillome canin (COPV) dont les codons sont optimisés afin d'améliorer l'expression dans des cellules hôtes.

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