Mri guided photodynamic therapy for cancer

Details Mri guided photodynamic therapy for cancer Mri guided photodynamic therapy for cancer

A - Human Necessities

61

K

A61K 39/385 (2006.01)

Patent

CA 2589881

Disclosed is a method of therapy used in combination with a diagnostic tool for enhanced photodynamic therapy using MRI, called (magnetic resonance imaging)-guided photodynamic therapy. The methods of the present invention includes administration of MRI contrast agent labeled polymer photosensitizer conjugates, detection and localization of tumor or cancer tissues with contrast-enhanced MRI and specific illumination and treatment of localized target tissues, such as tumors or cancer cells, using laser energy. The delivered laser energy activates the photosentizer accumulated in the target tissue, resulting in treatment. Also disclosed are novel conjugate compounds, such as PLGA-Mce6-DOTA-Gd complexes, having multi-functionality in that the complex may include an MRI contrasting agent linked to a photosensitizing agent.

L'invention concerne une méthode thérapeutique combinée à un outil de diagnostic pour obtenir une thérapie photodynamique améliorée par IRM, désignée sous le nom de thérapie photodynamique guidée par imagerie par résonance magnétique. Les méthodes de la présente invention consistent à administrer des conjugués polymères-photosensibilisants associés à un agent de contraste IRM, à détecter et à localiser des tissus tumoraux ou cancéreux par IRM améliorée par contraste et à l'aide d'un éclairage spécifique, et à traiter des tissus cibles localisés, tels que des cellules tumorales ou cancéreuses, par thérapie laser. L'énergie laser distribuée active le photosensibilisant accumulé dans le tissu cible, facilitant le traitement. L'invention concerne également de nouveaux composés conjugués, tels que des complexes PLGA-Mce6-DOTA-Gd, à multi-fonctionnalité, le complexe pouvant contenir un agent de contraste IRM associé à un agent photosensibilisant.

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