3-(1h-indazol-3-yl)-4-pyridinamines, a process and...

Details 3-(1h-indazol-3-yl)-4-pyridinamines, a process and... 3-(1h-indazol-3-yl)-4-pyridinamines, a process and...

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/44 (2006.01) C07D 213/72 (2006.01) C07D 213/73 (2006.01) C07D 213/75 (2006.01)

Patent

CA 2050875

3-(1H-Indazol-3-yl)-4-pyridinamines, a process and intermediates for their preparation and their use as medicaments This Invention relates to 4-(1H-indazol-3-yl)-4-pyridinamines of the formula I (see formula I) where R1 is hydrogen, loweralkyl, arylalkyl or acyl; R2 is hydrogen, loweralkyl or arylalkyl; R3 is hydrogen, loweralkyl or aryl and X is hydrogen, halogen, nitro or amino, or the pharmaceutically acceptable addition salts thereof, and where applicable, the geometric and optical isomers and racemic mixtures thereof. The compounds of this invention are useful as analgesics and as topical antiinflammatory agents for the treatment of various dermatoses. The invention relates further to intermediates of the formula II (see formula II) where R1, R2 and R3 have the above meaning, which have also analgesic activity, as well as to processes for the preparation of compounds of both formulae.

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