Bonding products of aminated polysaccharides

Details Bonding products of aminated polysaccharides Bonding products of aminated polysaccharides

C - Chemistry, Metallurgy

08

L

C08L 3/04 (2006.01) A61K 8/73 (2006.01) A61K 31/715 (2006.01) A61L 15/28 (2006.01) A61L 24/08 (2006.01) A61P 17/02 (2006.01) C08L 5/10 (2006.01)

Patent

CA 2755829

The invention relates to a bonding product comprising at least the polysaccharides T1 and T2, characterized in that a) the monosaccharides from which the polysaccharides T1 and T2 are constructed are partially or completely bonded to each other alpha-1,4-glycosidically and b) at least one of the polysaccharides T1 and/or T2 comprises at least one amino group and c) T1 and T2 are chemically bonded to each other covalently by at least one linker Z and d) T1 and/or T2 carries m groups -(L-A), wherein A is an active pharmaceutical ingredient and/or a fluorescence label, L is a second linker, by which T1 and/or T2 is covalently bonded to A, and m is an integer, which is 0 or at least 1.

L'invention concerne un produit de liaison comprenant au moins les polysaccharides T1 et T2, ce produit étant caractérisé en ce que a) les monosaccharides composant les polysaccharides T1 et T2 sont liés entre eux partiellement ou totalement par une liaison alpha-1,4-glycosidique, b) au moins un des polysaccharides T1 et/ou T2 présente au moins un groupe amino, c) T1 et T2 sont liés entre eux par une liaison chimique covalente au moyen d'au moins un lieur Z et d) T1 et/ou T2 portent m groupes -(L-A), A étant un principe actif pharmaceutique et/ou un marqueur fluorescent, L un second lieur au moyen duquel T1 et/ou T2 sont liés avec A par covalence, et m un nombre entier égal à 0 ou au moins à 1.

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