Acapsular p. multocida hyae deletion mutants

A - Human Necessities – 61 – K

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A61K 39/102 (2006.01) C12N 1/20 (2006.01)

Patent

CA 2530779

A capsular hyaE deletion mutants of P. multocida can be administered to mammals, particularly ungulates, or birds to provide protective immunity against wild-type P. multocida, e.g., to prevent or reduce the severity of hemorrhagic septicemia or pneumonia in mammals, particularly livestock, ungulates, and companion animals, or fowl cholera in birds, particularly poultry.

L'invention concerne un mutant acapsulaire de délétion d'un gène hyaE de<I> P. multocida</I>, qui peut être administré à des mammifères, en particulier des ongulés ou des volatiles, pour leur conférer une immunité protectrice contre <I>P. multocida </I>de type sauvage, par exemple pour prévenir ou atténuer la virulence d'une septicémie hémorragique ou d'une pneumonie chez lesdits mammifères, notamment le bétail, les ongulés et les animaux de compagnie; ou du choléra aviaire chez les volatiles, notamment la volaille.

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