A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/20 (2006.01)
Patent
CA 2727206
The present invention relates to a novel process for making oral solid gastro- retentive forms, comprising the steps of providing a powder mixture comprising a hydrophobic powder, overgranulating this powder mixture with a granulating solu-tion into an overgranulated paste, and drying said paste into a solid, as well as to pharmaceutical solid dosage forms which are re-tained in the stomach or upper gastrointestinal tract for a controlled delivery of a drug.
La présente invention concerne un nouveau procédé permettant la fabrication de formes pharmaceutiques orales solides à rétention gastrique, qui comprend les étapes suivantes : fourniture dun mélange de poudre comprenant une poudre hydrophobe ; surgranulation dudit mélange de poudre avec une solution de granulation pour obtenir une pâte surgranulée ; et séchage de ladite pâte pour former un solide. Linvention concerne également des formes pharmaceutiques solides qui sont retenues dans lestomac ou dans le tractus gastro-intestinal supérieur pour permettre la libération contrôlée dun médicament.
Prinderre Pascal
Sauzet Christophe
Gowling Lafleur Henderson Llp
Universite de La Mediterranee
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