Methods and compositions for assessment of pulmonary...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01)

Patent

CA 2449647

The present invention is concerned with methods for the assessment of pulmonary function and/or disorders, and in particular for diagnosing predisposition to and/or severity of chronic obstructive pulmonary disease in smokers and non-smokers usins analysis of genetic polymorphisms and altered gene expression, particularly with regard to genes involved in matrix remodelling, anti-oxidant defence and the inflammatory response.

L'invention concerne des procédés d'évaluation de la fonction et/ou des troubles pulmonaires, en particulier des méthodes permettant de diagnostiquer une prédisposition à la broncho-pneumopathie chronique obstructive et/ou la gravité de celle-ci chez les fumeurs et chez les non-fumeurs, cette méthode consistant à analyser les polymorphismes génétiques et les expressions géniques modifiées, en particulier pour les gènes impliqués dans le remodelage de la matrice, la défense antioxydante et la réponse inflammatoire.

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