Hydroxamate-based inhibitors of deacetylases b

Details Hydroxamate-based inhibitors of deacetylases b Hydroxamate-based inhibitors of deacetylases b

C - Chemistry, Metallurgy

07

D

C07D 207/08 (2006.01) A61K 31/4025 (2006.01) A61P 35/00 (2006.01) C07D 401/06 (2006.01) C07D 403/06 (2006.01) C07D 405/06 (2006.01) C07D 413/06 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2719477

The present teachings relate to compounds of Formula (I) and pharmaceutically acceptable salts, hydrates, esters, and prodrugs thereof, wherein R1, R2, R3, Y, Z, and (A) are as defined herein. The present teachings also provide methods of preparing compounds of Formula (I) and methods of using compounds of Formula (I) in treating, inhibiting, or preventing pathologic conditions or disorders mediated wholly or in part by deacetylases.

Cette invention concerne des composés de Formule (I) et des sels, des hydrates, des esters, et des promédicaments pharmaceutiquement acceptables de ceux-ci. Dans la Formule (I), R1, R2, R3, Y, Z, et (A) sont tels que définis ici. La présente invention concerne également des procédés de préparation des composés de Formule (I) et des procédés d'utilisation des composés de Formule (I) pour traiter, inhiber, ou prévenir des états pathologiques ou des troubles médiés en tout ou partie par des désacétylases.

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