Hydroxyquinolone derivatives

Details Hydroxyquinolone derivatives Hydroxyquinolone derivatives

C - Chemistry, Metallurgy

07

D

C07D 215/22 (2006.01) A61K 31/47 (2006.01) A61K 31/535 (2006.01) C07D 401/02 (2006.01) C07D 401/12 (2006.01) C07D 403/10 (2006.01) C07D 405/02 (2006.01) C07D 405/04 (2006.01) C07D 405/10 (2006.01) C07D 405/12 (2006.01) C07D 409/02 (2006.01) C07D 409/10 (2006.01) C07D 409/12 (2006.01) C07D 413/02 (2006.01)

Patent

CA 2053465

T1083 ABSTRACT HYDROXYQUINOLONE DERIVATIVES A class of 4-hydroxy-2-(1H)-quinolone derivatives, substituted at the 3-position by an optionally substituted aryl substituent, are selective non-competitive antagonists of NMDA receptors and/or are antagonists of AMPA receptors, and are therefore of utility in the treatment of conditions, such as neurodegenerative disorders, convulsions or schizophrenia, which require the administration of an NMDA and/or AMPA receptor antagonist.

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