Vasoactive kit and composition and uses thereof

Details Vasoactive kit and composition and uses thereof Vasoactive kit and composition and uses thereof

A - Human Necessities

61

K

A61K 9/12 (2006.01) A61K 9/107 (2006.01) A61K 9/19 (2006.01) A61K 31/045 (2006.01) A61K 31/20 (2006.01) A61P 17/00 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2609948

The present invention relates to a therapeutic kit to provide a safe and effective dosage of a vasoactive agent, including an aerosol packaging assembly including: a container accommodating a pressurized product; and an outlet capable of releasing the pressurized product as a foam, wherein the pressurized product comprises a foamable composition including: a vasoactive agent; at least one organic carrier selected from the group consisting of a hydrophobic organic carrier, an organic polar solvent, an emollient and mixtures thereof, at a concentration of about 2% to about 50% by weight, a surface- active agent, about 0.01% to about 5% by weight of at least one polymeric additive selected from the group consisting of a bioadhesive agent, a gelling agent, a film forming agent and a phase change agent, water; and liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.

La présente invention concerne un kit thérapeutique permettant de produire une dose sans risque et efficace d'un agent vasoactif et comprenant un ensemble d'emballage en aérosol comprenant: un récipient renfermant un produit sous pression; et un orifice de sortie capable de libérer le produit sous pression sous forme de mousse, le produit sous pression renfermant une composition moussante contenant: un agent vasoactif; au moins un excipient organique sélectionné dans le groupe comprenant un excipient organique hydrophobe, un solvant polaire organique, un émollient et des mélanges de ceux-ci, à une concentration d'environ 2 à environ 50 % en poids; un agent tensioactif; d'environ 0,01 à environ 5 % en poids d'au moins un additif polymère sélectionné dans le groupe comprenant un agent bioadhésif, un agent gélifiant, un agent filmogène et un agent à changement de phase; de l'eau; et un gaz propulseur liquéfié ou comprimé à une concentration d'environ 3 à environ 25 % en poids de la composition totale.

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