Processes for manufacturing bisphosphonic acids

Details Processes for manufacturing bisphosphonic acids Processes for manufacturing bisphosphonic acids

C - Chemistry, Metallurgy

07

F

C07F 9/38 (2006.01) C07F 9/58 (2006.01) C07F 9/6506 (2006.01)

Patent

CA 2689504

Processes are provided for preparing bisphosphonic acids, wherein phosphorous acid and phosphorous halide compound are fed into composition comprising imidazole-1 - ylacetic acid, or the like, and polar solvent; the reaction mixture remains stirrable and is quenched by inputting into water; and after cooling, bisphosphonic acid can be isolated, wherein R1 comprises: i) CH3 , Formulae ii), iii), iv), v), vi), vii), viii) and ix).

La présente invention concerne des procédés de préparation d'acides bisphosphoniques, dans lesquels l'acide phosphoreux et le composé halogéné phosphoreux sont chargés à l'intérieur de la composition comprenant l'acide imidazole-1-ylacétique, ou équivalent, et un solvant polaire ; le mélange réactionnel reste possible à agiter et est désactivé en le mettant dans l'eau ; et après refroidissement, l'acide bisphosphonique peut être isolé, R1 comprenant : i) CH3 , Formules ii), iii), iv), v), vi), vii), viii) et ix).

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