Novel human transmembrane 4 superfamily protein

Details Novel human transmembrane 4 superfamily protein Novel human transmembrane 4 superfamily protein

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/00 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 1/21 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2282736

The present invention provides a novel human integral membrane (TMP-1) and polynucleotides which identify and encode TMP-1. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding TMP-1 and a method for producing TMP-1. The invention also provides for agonists, antibodies, or antagonists specifically binding TMP-1, and their use, in the prevention and treatment of diseases associated with expression of TMP-1. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding TMP-1 for the treatment of diseases associated with the expression of TMP-1. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding TMP-1.

L'invention concerne une nouvelle membrane intégrale (TMP-1) humaine et des polynucléotides qui identifient et codent TMP-1. Elle porte aussi sur des vecteurs d'expression génétiquement modifiés, sur des cellules hôtes comprenant les séquences nucléotidiques codant TMP-1 et sur un procédé de production de TMP-1. Elle se rapporte encore à des agonistes, à des anticorps ou à des antagonistes fixant spécifiquement TMP-1, et leur utilisation dans la prévention et le traitement de maladies associées à l'expression de TMP-1. De plus, elle concerne l'utilisation de molécules antisens dirigées contre des polynucléotides codant TMP-1, pour le traitement de maladies associées à l'expression de TMP-1 ainsi que des essais diagnostiques dans lesquels on utilise le polynucléotides, des fragments ou le compléments de ceux-ci, et des anticorps fixant spécifiquement TMP-1.

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