C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) A61K 31/282 (2006.01) A61K 31/337 (2006.01) A61K 31/407 (2006.01) A61K 31/4745 (2006.01) A61K 31/475 (2006.01) A61K 31/496 (2006.01) A61K 31/506 (2006.01) A61K 31/513 (2006.01) A61K 31/519 (2006.01) A61K 31/52 (2006.01) A61K 31/675 (2006.01) A61K 31/704 (2006.01) A61K 31/7048 (2006.01) A61K 31/7068 (2006.01) A61K 31/7076 (2006.01) A61K 33/24 (2006.01) A61K 38/00 (2006.01) A61K 38/21 (2006.01) A61K 38/46 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61P 35/00 (2006.01) A61P 43/0
Patent
CA 2585638
A compound represented by the following general formula [I] or its pharmaceutically acceptable salt or ester, an Aurora-A selective inhibitor or an anticancer agent containing the same, and the combined use of the above anticancer agent with another anticancer agent: [I] wherein m1 and m2 represent each 1, 2 or 3; n1 and n2 represent each 0 or 1; i is an integer of from 1 to m1; j is an integer of from 1 to m2; R represents optionally substituted aryl, heteroaryl or cycloalkyl; Ral and Ral~ represent each hydrogen, etc.; Rbj and Rbj~ represent each hydrogen, etc.; Rc, Rd and Re represent each hydrogen, etc.; X1 represents CH, CX1a or N; X2 represents CH, N, etc.; X3 represents CH, N, etc.; X4 represents CH, N, etc.; Y1, Y2 and Y3 are the same or different and each represents CH or N; Z1 and Z2 are the same or different and each represents CH or N; and W represents a 5-membered aromatic heterocycle such as pyrazole or thiazole.
L'invention concerne un composé de formule (I) ou un sel ou un ester pharmaceutiquement acceptable de celui-ci, un inhibiteur sélectif d'aurora-A ou un agent anticancéreux contenant celui-ci, ainsi que l'utilisation combinée de l'agent cancéreux susmentionné et d'un autre agent anticancéreux. Dans la formule (I), m1 et m2 désignent chacun 1, 2 ou 3; n1 et n2 désginent chacun 0 ou 1; i désigne un nombre entier compris entre 1 et m1; j désigne un nombre entier compris entre 1 et m2; R désgine aryle, hétéroaryle ou cycloalkyle éventuellement substitué; Ral et Ral' désignent chacun hydrogène, etc.; Rbj et Rbj' désignent chacun hydrogène, etc.; Rc, Rd et Re désignent chacun hydrogène, etc.; X1 désigne CH, CX1a ou N; X2 désigne CH, N, etc.; X3 désigne CH, N, etc.; X4 désigne CH, N, etc.; Y1, Y2 et Y3 sont identiques ou différents, et chacun désigne CH ou N; Z1 et Z2 sont identiques ou différents, et chacun désigne CH ou N; et W désigne un hétérocycle aromatique à 5 éléments, notamment du pyrazole ou du thiazole.
Kato Tetsuya
Kawanishi Nobuhiko
Mita Takashi
Ohkubo Mitsuru
Shimomura Toshiyasu
Banyu Pharmaceutical Co. Ltd.
Msd K.k.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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