C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 223/12 (2006.01) A61K 31/55 (2006.01) C07D 207/14 (2006.01) C07D 211/56 (2006.01) C07F 7/10 (2006.01)
Patent
CA 2225616
Compounds of general formula (I), wherein R1 is phenyl or alpha- or beta- naphthyl, which groups can be substituted by hydroxy, lower-alkyl, lower- alkoxy, lower alkoxy-carbonyl, phenoxy, acyloxy, hydroxyphenoxy-sulfonyl, halogen, nitro, amino, acylamino or N-lower-alkyl-acylamino; R2 is phenyl or phenyl substituted by hydroxy or acyloxy; Y is a carbon-carbon bond or is vinylene; and n is 1, 2 or 3; and pharmaceutically acceptable acid addition salts thereof are protein kinase inhibitors and can be used for the treatment of disorders mediates by such enzymes, e.g., inflammatory diseases.
Les composés de formule générale (I) dans laquelle R?1¿ est phényle ou alpha- ou bêta-naphtyle, ces groupes pouvant être substitués par hydroxy, alkyle inférieur, alcoxy inférieur, alcoxy-carbonyl de faible PM, phénoxy, acyloxy, hydroxyphénoxy-sulfonyle, halogène, nitro, amino, acylamino ou N-alkylacylamino inférieur; R?2¿ est phényle ou phényle substitué par hydroxy ou acyloxy; Y est une liaison carbone-carbone ou est vinylène; et n vaut 1, 2 ou 3; ainsi que leurs sels d'addition acide pharmaceutiquement acceptables, sont des inhibiteurs de la protéine kinase et peuvent être utilisés pour le traitement des troubles dont celle-ci est le médiateur, tels que les maladies inflammatoires.
Barbier Pierre
Stadlwieser Josef
Taylor Sven
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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