Stereoselective synthesis of nucleoside analogues

Details Stereoselective synthesis of nucleoside analogues Stereoselective synthesis of nucleoside analogues

C - Chemistry, Metallurgy

12

P

C12P 41/00 (2006.01)

Patent

CA 2362570

The present invention provides a process for making stereochemically pure dioxolane nucleoside analogues. The process includes the use of hydrolytic enzymes for separating .beta. and .alpha. anomers from an anomeric mixture represented by formula (A) or formula (B) wherein W is benzyl or benzoyl; R1 is selected from the group consisting of C1-6 alkyl and C6-15 aryl.

L'invention concerne un procédé de fabrication d'analogues nucléosidiques de dioxolane purs au plan stéréochimique. Ledit procédé consiste à utiliser l'enzyme hydrolytique pour la séparation des anomères .beta. et .alpha. d'un mélange anomère représenté par la formule A ou la formule B, dans lesquelles W représente benzyle ou benzoyle ; R¿1? est choisi dans le groupe constitué d'alkyle C¿1-6? et d'aryle C¿6-15?.

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