Human prostate specific g-protein receptor hpraj70

Details Human prostate specific g-protein receptor hpraj70 Human prostate specific g-protein receptor hpraj70

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/16 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) C07K 14/705 (2006.01) C07K 14/71 (2006.01) C07K 14/72 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) C12N 15/64 (2006.01) C12N 15/66 (2006.01) C12P 21/00 (2006.01) C12P 21/02 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2422642

The present invention relates to PSGR, a novel prostate specific gene with homology to a G-protein coupled receptor overexpressed in prostate cancer. More specifically, the invention relates to PSGR polynucleotides and the polypeptides encoded by these polynucleotides, and the use of PSGR polynucleotides and polypeptides for detecting disorders of the reproductive system, including disorders of the prostate, particularly the presence of cancer. This invention relates to PSGR polynucleotides and polypeptides as well as vectors, host cells, antibodies directed to PSGR polynucleotides and polypeptides and recombinant and synthetic methods for producing the same. Also provided are methods for diagnosing, treating, preventing and/or prognosing disorders related to the prostate, including cancer. The invention further relates to screening methods for identifying agonists and antagonists of PSGR polynucleotides and polypeptides of the invention and methods and/or compositions for inhibiting or enhancing the production and/or function of the PSGR polypeptides of the present invention.

La présente invention concerne un gène spécifique de la prostate, dit PSGR, à homologie avec un récepteur couplé à la protéine G, qui est surexprimé dans le cancer de la prostate. Plus spécialement, l'invention concerne des polynucléotides PSGR et des polypeptides qui codent ces polynucléotides, ainsi que l'utilisation desdits polynucléotides et polypeptides pour la détection de troubles du système reproductif, dont les troubles de la prostate, en particulier la présence d'un cancer. Cette invention concerne des polynucléotides et des polypeptides PSRG ainsi que des vecteurs, cellules hôtes, anticorps dirigés vers des polynucléotides et polypeptides PSGR ainsi que des méthodes recombinantes et synthétiques de production desdits polynucléotides et polypeptides. Sont également décrites des méthodes de diagnostic, de traitement et/ou de pronostic de troubles de la prostate, dont le cancer. De plus, l'invention concerne des procédés de criblage permettant d'identifier des agonistes et des antagonistes des polynucléotides et polypeptides PSGR selon l'invention ainsi que des méthodes et/ou des compostions permettant d'inhiber ou d'accentuer la production et/ou la fonction desdits polypeptides.

Affiliated with

Also associated with

Rating

Human prostate specific g-protein receptor hpraj70 does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Human prostate specific g-protein receptor hpraj70, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human prostate specific g-protein receptor hpraj70 will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1836623