Fluorescent agents for real-time measurement of organ function

Details Fluorescent agents for real-time measurement of organ function Fluorescent agents for real-time measurement of organ function

A - Human Necessities

61

K

A61K 49/00 (2006.01) A61K 49/10 (2006.01)

Patent

CA 2418206

A fluorescent agent for monitoring organ function, such as glomerular filtration, renal blood flow, or hepatic function. The agent is injected into a subject and the fluorescence monitored in vivo via time-resolved fluorescent techniques. The agent is a lanthanide ion chelated to a polyaminopolyacetic acid analog. A new clearance agent is also proposed based on a tetraazamacrocycle. Such a clearance agent also finds applications in other fields where fluorescence detection is exploited.

La présente invention concerne un agent fluorescent utile pour surveiller le fonctionnent d'un organe, tel que la filtration glomérulaire, le débit rénal sanguin ou la fonction hépatique. L'agent est injecté à un patient et la fluorescence est surveillée in vivo au moyen de techniques de fluorescence en temps différé. L'agent est un ion lanthanide chélaté à un analogue d'acide polyaminopolyacétique. Un nouvel agent de clairance à base d'un tétraazamacrocycle est également présenté, cet agent de clairance pouvant également être utilisé dans d'autres domaines dans lesquels la détection par fluorescence est employée.

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