Lck-derived peptides activating ctls

Details Lck-derived peptides activating ctls Lck-derived peptides activating ctls

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/10 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07K 7/00 (2006.01) C07K 14/82 (2006.01) C12N 9/12 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2381348

A tumor antigen peptide capable of inducing and/or activating HLA-A24-restricted and/or HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes functions by providing a polynucleotide encoding the peptide and a complementary strand thereto, a recombinant vector containing the polynucleotide, a transformant containing the recombinant vector, a method for producing the peptide, an antibody against the peptide, a compound interacting with these entities and a method for screening for the compound, a pharmaceutical composition utilizing these entities, and a means for the diagnosis utilizing these entities.

Cette invention se rapporte à un peptide d'antigène de tumeur, capable d'induire et/ou d'activer des lymphocytes T cytotoxiques spécifiques aux tumeurs de réduction de l'antigène HLA-A24 et/ou HLA-A2; à un polynucléotide codant ce peptide ou son brin complémentaire; à un vecteur recombiné contenant ce polynucléotide; à un transformant contenant ce vecteur recombiné; à un procédé de production de ce peptide; à un anticorps dirigé contre ce peptide; à un composé ayant des interactions avec ces substances; à un procédé de criblage de ce composé; à des compositions médicales produites à l'aide de ces substances; et à un moyen de diagnostic utilisant ces substances.

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