Enantiomeric resolution

Details Enantiomeric resolution Enantiomeric resolution

C - Chemistry, Metallurgy

07

C

C07C 57/30 (2006.01) C07B 57/00 (2006.01) C07C 51/41 (2006.01) C07C 51/487 (2006.01) C07C 59/64 (2006.01) C07C 211/27 (2006.01) C07C 253/34 (2006.01) C07C 255/41 (2006.01) C07D 213/80 (2006.01) C07D 307/68 (2006.01) C07D 333/38 (2006.01)

Patent

CA 2146777

A process for obtaining a substantially pure enantiomer of an aryl-substituted aliphatic carboxylic acid is described. The process utilizes first an enantiomerically enriched mixture of the aryl-substituted aliphatic carboxylic acid obtained from kinetic resolution, diastereomeric crystallization or asymmetric synthesis processes. This enriched mixture is reacted with a base produ- cing a salt that has the following properties: (I) has at least one eutectic point; (2) a composition that is not at the eutectic point; and (3) a eutectic composition that is closer to the racemic composition than is the eutectic composition of said aryl-substituted carboxylic acid. Substantially pure, enantiomeric salt is separated, leaving a mother liquor comprising the solvent and aryl-substi- tuted aliphatic carboxlyic acid enriched in the other enantiomer.

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