Imaging of activated vascular endothelium using...

A - Human Necessities – 61 – K

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A61K 49/18 (2006.01) A61B 5/055 (2006.01) A61K 49/00 (2006.01)

Patent

CA 2668457

lmmunomagnetic nanoparticles are used as a contrast agent for enhancing medical diagnostic imaging such as magnetic resonance imaging (MRI). The present invention is directed to methods of making targeted MRI contrast agents from immunomagnetic particles, and to methods of using such MRI contrast agents. Typically, such targeted MRI contrast agents provide enhanced relaxivity, improved signal-to-noise, targeting ability, and resistance to agglomeration. Methods of making such MRI contrast agents typically afford better control over particle size, and methods of using such MRI contrast agents typically can afford enhanced blood clearance rates and distribution. The ability to use the contrast agents im MRI provides a tool in the diagnosis and treatment of several disease states.

On utilise des nanoparticules immunomagnétiques comme agent de contraste afin d'améliorer l'imagerie de diagnostic médical telle que l'imagerie par résonance magnétique (IRM). Cette invention concerne des procédés de fabrication d'agents de contraste cibles pour IRM à partir de nanoparticules, ainsi que des méthodes d'utilisation de tels agents de contraste pour IRM. De façon générale, de tels agents de contraste ciblés pour IRM offrent une meilleure relaxivité, un rapport signal-bruit amélioré, ainsi qu'une aptitude au ciblage et une résistance à l'agglomération. Les procédé d'obtention de tels agents de contraste pour IRM permettent en général une meilleure maîtrise de la taille des particules, cependant que les méthodes d'emploi de ces agents autorisent généralement de meilleurs taux de clairance du sang et une meilleure distribution. La possibilité d'utiliser ces agents de contraste dans l'IRM fournit un outil de diagnostic et de traitement pour plusieurs états pathologiques.

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