Quinolone and tetrahydroquinoline and related compounds...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 409/14 (2006.01) A61K 31/4709 (2006.01) A61K 31/55 (2006.01) C07D 209/04 (2006.01) C07D 215/02 (2006.01) C07D 223/16 (2006.01) C07D 409/12 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2681771

The present invention features quinolones, tetrahydroquinolines, and related compounds that inhibit nitric oxide synthase (NOS), particularly those that selectively inhibit neuronal nitric oxide synthase (nNOS) in preference to other NOS isoforms. The NOS inhibitors of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing various medical conditions.

La présente invention porte sur des quinolones, des tétraydroquinoléines et des composés apparentés qui inhibent l'oxyde nitrique synthase (NOS), en particulier sur celles et ceux qui inhibent de façon sélective l'oxyde nitrique synthase neuronal (nNOS) de préférence à d'autres isoformes de NOS. Les inhibiteurs de NOS de l'invention, individuellement ou en combinaison avec d'autres agents pharmaceutiquement actifs, peuvent être utilisés pour traiter ou prévenir divers états médicaux.

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