A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/00 (2006.01) C12N 5/078 (2010.01) A61K 35/12 (2006.01) A61P 37/04 (2006.01) C12N 15/00 (2006.01) C12N 15/62 (2006.01) C07K 19/00 (2006.01) C12N 15/85 (2006.01)
Patent
CA 2738031
Provided are methods for activating an antigen-presenting cell and eliciting an immune response by inducing an inducible pattern recognition receptor adapter, or adapter fragment, and CD40 activity. Also provided are nucleic acid compositions comprising sequences coding for chimeric proteins that include an inducible CD40 peptide and an inducible pattern recognition receptor adapter or adapter fragment.
La présente invention concerne des procédés permettant lactivation dune cellule présentatrice de lantigène et la provocation dune réponse immunitaire par linduction dun adaptateur de récepteur, ou un fragment dadaptateur, de reconnaissance de motifs inductible, et une activité de CD40. Linvention concerne également des compositions dacides nucléiques comportant des séquences codant pour des protéines chimériques qui comprennent un peptide CD40 inductible et un adaptateur de récepteur ou un fragment dadaptateur de reconnaissance de motifs inductible
Priyadharshini Narayanan
Spencer David
Baylor College Of Medicine
Smart & Biggar
LandOfFree
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