Substituted 4-phenyltetrahydroisoquinolines, process for...

Details Substituted 4-phenyltetrahydroisoquinolines, process for... Substituted 4-phenyltetrahydroisoquinolines, process for...

C - Chemistry, Metallurgy

07

D

C07D 217/22 (2006.01) A61K 31/47 (2006.01) A61P 9/12 (2006.01) C07D 217/18 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2469385

The invention relates to compounds of formula (I), wherein R1 - R9 which have the meaning as cited in the claims, are extremely suitable as antihypertensives for reducing or preventing ischemically induced injuries, as medicaments for operative intervention for the treatment of ischemics of the nervous system, strokes and swelling of the brain, shocks, disturbed respiratory functions, for the treatment of snorers, as a laxative, as agents against ectopic parasites, for the prevention of gallstones, as antiatherosclerotic agents, agents against diabetic late complications, cancer, fibrotic diseases, endothelial dysfunctions, organ hypertrophia and hyperplasia. Said compounds are also inhibitors of the cellular sodium-proton- antiporters, they influence serum lipoproteins and can be used in the prophylaxis of and for the regression of atherosclerotic alterations.

Des composés de formule (I) dans laquelle R1 à R9 ont les significations données dans les revendications, sont remarquablement appropriés comme agents hypertenseurs pour réduire ou empêcher des insuffisances d'origine ischémique, comme médicaments pour des interventions pour le traitement d'ischémies du système nerveux, d'infarctus cérébral et d'oedème cérébral, d'états de choc, de fonctions respiratoires perturbées, pour le traitement du ronflement, comme laxatifs, comme agents contre des parasites ectopiques, pour la prévention de calculs biliaires, comme agents de lutte contre l'athérosclérose, agents contre des complications tardives du diabète, contre les cancers, maladies fibrotiques, dysfonctions endothéliales, hypertrophies et hyperplasies des organes. Lesdits composés sont également des inhibiteurs des antiports-protons-sodium. Ils influencent les lipoprotéines du sérum et peuvent en conséquence être utilisés en prophylaxie et pour la régression de modifications de l'athérosclérose.

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