Amphotericin b aqueous composition

Details Amphotericin b aqueous composition Amphotericin b aqueous composition

A - Human Necessities

61

K

A61K 47/24 (2006.01) A61K 9/10 (2006.01) A61K 31/7048 (2006.01) A61P 31/04 (2006.01) A61L 2/07 (2006.01)

Patent

CA 2438847

A low toxicity parenteral dimethyl sulfoxide free aqueous compositions containing Amphotericin B are described. The compositions essentially consist of in addition to Amphotericin B, phospholipids and sodium chloride. The compositions are sterilised by autoclaving. The process of making these compositions without the use of solvents for dissolving Amphotericin B have been described. The compositions are indicated for the treatment of invasive fungal infections.

L'invention concerne des compositions aqueuses exemptes de diméthylsulfoxyde parentéral à faible toxicité contenant de l'amphotérocine B. Ces compositions sont essentiellement constituées, en sus de l'amphotérocine B, de phospholipides et de chlorure de sodium. Ces compositions sont stérilisées par stérilisation en autoclave. Le procédé de fabrication desdites compositions ne nécessite pas d'utiliser de solvants pour dissoudre l'amphotérocine B. Lesdites compositions sont indiquées pour le traitement d'infections fongiques invasives.

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