Polymer-based osmotic drug delivery system

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/26 (2006.01) A61K 9/00 (2006.01) A61K 9/20 (2006.01) A61K 38/18 (2006.01) A61K 38/47 (2006.01)

Patent

CA 2122835

Described herein is a drug delivery system useful to deliver drugs at low dosage levels to patients in a sustained fashion and at a controlled rate. The system comprises a wettable polymeric matrix in which is dispersed a multiplicity of particles con- taining a substantially homogeneous blend of osmotically active recipient and not more than about 10 % by weight of drug. The system is particularly well suited for delivery of therapeutic macr?molecules such as protein drugs. Delivery of epidermal growth factor is exemplified.

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