A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01) A61K 31/337 (2006.01) A61K 47/36 (2006.01) A61P 9/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C08B 37/08 (2006.01)
Patent
CA 2502531
The present invention relates to water-soluble taxanes covalently bounded tohyaluronic acid or hyaluronic acid derivatives, and in particular to paclitaxel and docetaxel, useful for the preparation of pharmaceutical compositions to be used in the field of oncology, in the treatment of autoimmune disorders and of restenosis. The invention also relates to the process for preparing taxanes covalently bounded to hyaluronic acid or hyaluronic acid derivatives by direct synthesis between molecules of hyaluronic acid and of taxane or by indirect synthesis by the introduction of a spacer between the hyaluronic acid or hyaluronic acid derivative and the taxane.
L'invention concerne des taxanes solubles dans l'eau, liés de manière covalente à un acide hyaluronique ou des dérivés d'acide hyaluroniques et en particulier un paclitaxel et un docetaxel, utilisé pour la préparation de compositions pharmaceutiques destinées à être utilisées dans le domaine de l'oncologie, dans le traitement de maladies auto-immunes et de resténose. L'invention concerne également le procédé de préparation de taxanes liés de manière covalente à un acide hyaluroniqe ou à des dérivés d'acide hyaluronique par synthèse directe entre des molécules d'acide hyaluronique et de taxanes ou par synthèse indirecte, grâce à l'introduction d'un espaceur entre l'acide hyaluronique ou les dérivés d'acide hyaluronique et les taxanes.
de Luca Gilda
Marini Bettolo Rinaldi
Migneco Luisa Maria
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Fidia Farmaceutici S.p.a.
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