Induction of tolerance by apoptotic and/or necrotic cells

Details Induction of tolerance by apoptotic and/or necrotic cells Induction of tolerance by apoptotic and/or necrotic cells

A - Human Necessities

61

K

A61K 35/28 (2006.01) A61K 35/12 (2006.01) A61K 35/26 (2006.01) A61K 39/00 (2006.01) C12N 5/02 (2006.01)

Patent

CA 2475021

The present invention is directed to a method of inducing tolerance to self- antigens in a subject having an autoimmune diseases. In particular, the invention provides a pharmaceutical composition and method of use thereof for the modulation of immunogical activity in an animal subject. Said modulation may be an increased tolerance to self apoptotic cells, a reduction in the tissue levels of autoantibodies associated with apoptotic cells, a reduction in the tissue levels of autoantibodies associated with an autoimmune disease, a reduction in the level of inflammation and inflammatory mediators associated with an autoimmune disease, a reduction in the level of tissue damage associated with an autoimmune disease, or a combination thereof.

La présente invention a trait à un procédé d'induction de tolérance à des auto-antigènes, chez un sujet souffrant d'une maladie auto-immune. L'invention concerne en particulier une composition pharmaceutique et un procédé d'utilisation de celle-ci pour la modulation de l'activité immunologique chez un sujet animal. Ladite modulation peut être une tolérance accrue aux cellules auto-apoptotiques, une réduction des concentrations tissulaires d'auto-anticorps associés à des cellules apoptotiques, une réduction des concentrations tissulaires d'auto-anticorps associés à une maladie auto-immune, une réduction de la concentration de médiateurs d'inflammation et inflammatoires associés à une maladie auto-immune, une réduction du niveau de dommages tissulaires associés à une maladie auto-immune ou une combinaison de plusieurs de ces éléments.

Affiliated with

Also associated with

Rating

Induction of tolerance by apoptotic and/or necrotic cells does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Induction of tolerance by apoptotic and/or necrotic cells, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Induction of tolerance by apoptotic and/or necrotic cells will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1842332