Base analogues

Details Base analogues Base analogues

C - Chemistry, Metallurgy

07

H

C07H 19/00 (2006.01) C07H 21/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2297776

Nucleoside analogues or base analogues having structure (I), where X = O or NH or S, Y = N or CHR6 or CR6, W = N or NR6 or CHR6 or CR6 or S, n = 1 or 2; each R6 is independently H or O or alkyl or alkenyl or alkoxy or aryl or a reporter moiety; where necessary (i.e. when Y and/or W is N or CR6 where R6 is not O) a double bond is present between Y and W or W and W, and Q is H or a sugar or a sugar analogue or a nucleic acid backbone or backbone analogue.

L'invention concerne des analogues de nucléosides ou analogues de bases représentés par la structure (I), dans laquelle X = O ou NH ou S; Y = N ou CHR?6¿ ou CR?6¿; W = N ou NR?6¿ ou CHR?6¿ ou CR?6¿ ou S; n = 1 ou 2; chaque R?6¿ est indépendamment H, O, alkyle, alcényle, alkoxy, aryle ou une fraction de ligand; lorsque c'est nécessaire (c.-à-d. quand Y et/ou W est N ou CR?6¿ là où R?6¿ n'est pas O), une double liaison est présente entre Y et W, ou entre W et W; et Q est H, un sucre, un analogue de sucre, un squelette d'acides nucléiques ou un analogue de squelette.

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