Method of restoring the incretin effect

Details Method of restoring the incretin effect Method of restoring the incretin effect

A - Human Necessities

61

K

A61K 31/475 (2006.01) A61P 3/00 (2006.01)

Patent

CA 2666846

The present invention relates to methods of treating metabolic syndrome, Type 2 diabetes mellitus, atherogenic dyslipidemia and/or obesity. The present invention also relates to methods of restoring the incretin effect, to restoring physiologic control of glucagon levels, to restoring first-phase insulin secretion, and to restoring the physiologic glucose-dependent insulin secretion. The methods of the present invention comprise administration of a selective .kappa.-receptor antagonist, such as guanidinylated naltrindole (GNTI), or pharmaceutically acceptable derivatives thereof to a subject in need thereof.

La présente invention concerne des procédés pour traiter un syndrome métabolique, le diabète sucré de type 2, une dyslipidémie athérogène et/ou l'obésité. La présente invention concerne également des procédés pour rétablir l'effet de l'incrétine, la régulation physiologique des niveaux de glucagon, la sécrétion d'insuline de première phase, et la sécrétion d'insuline dépendant du glucose physiologique. Les procédés de la présente invention comportent l'administration d'un antagoniste de récepteur k sélectif, comme le naltrindole guanidinylé (GNTI), ou ses dérivés acceptables du point de vue pharmaceutique, à un patient qui en a besoin.

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