Nucleic and proteinic acids corresponding to human gen abc1

Details Nucleic and proteinic acids corresponding to human gen abc1 Nucleic and proteinic acids corresponding to human gen abc1

C - Chemistry, Metallurgy

12

N

C12N 15/52 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2375771

The invention relates to nucleic acids corresponding to different exons and introns of gene ABC1 which is shown to be a gene causing pathologies linked to cholesterol metabolism dysfunction causing diseases such as atherosclerosis, more particularly perturbation of reverse cholesterol transport and more particularly of FHD's such as Tangier disease.

La présente invention concerne des acides nucléiques correspondant aux différents exons et introns du gène ABC1, dont il est présentement démontré qu'il est un gène causal de pathologies liées à un dysfonctionnement du métabolisme du cholestérol induisant des maladies comme l'athérosclérose, plus particulièrement des perturbations du transport inverse du cholestérol, et plus particulièrement des déficiences familiales en HDL (FHD), comme la maladie de Tangier.

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