G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/574 (2006.01)
Patent
CA 2735853
The present invention concerns a method for predicting the potential for aggressive growth and/or the risk to progress to high grade cancer for tumors in cell based detection procedures. In one aspect the invention concerns the detection of overexpression of cyclin-dependent kinase inhibitor gene products as a tool for predicting the progression risk and/or potential for aggressive growth of tumors. In a second aspect the invention concerns predicting the progression risk and/or potential for aggressive growth in tumors on the basis of the simultaneous co-detection of the presence of overexpression of cyclin-dependent kinase inhibitor gene products together with the expression of markers for active cell proliferation. Further the invention concerns preparations of probes for diagnosis namely for predicting the progression risk and/or the potential for aggressive growth of tumors.
La présente invention concerne un procédé permettant, sur la base de procédures de détection de cellules, de prédire le potentiel de croissance agressive et/ou le risque que des tumeurs évoluent en un cancer caractérisé. Par un aspect, l'invention concerne la détection de la surexpression de produits géniques inhibiteurs de kinases cyclino-dépendantes, laquelle détection constitue un moyen de prédire le risque de progression et/ou le potentiel de croissance agressive de tumeurs. Par un second aspect, l'invention concerne la prédiction du risque de progression et/ou du potentiel de croissance agressive de tumeurs sur la base de la détection de la présence de surexpression de produits géniques inhibiteurs de kinases cyclino-dépendantes concomitamment avec la détection de l'expression de marqueurs de prolifération cellulaire active. L'invention concerne également des préparations de sondes de diagnostic particulièrement destinées à la prédiction du risque de progression et/ou du potentiel de croissance agressive de tumeurs.
Martin Peter
Ridder Ruediger
Mtm Laboratories Ag
Roche Mtm Laboratories Ag
Smart & Biggar
LandOfFree
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