Receptor and transporter antagonists

Details Receptor and transporter antagonists Receptor and transporter antagonists

C - Chemistry, Metallurgy

07

K

C07K 14/705 (2006.01) A01K 67/027 (2006.01) A61K 31/70 (2006.01) A61K 35/12 (2006.01) A61K 38/07 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/16 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 5/10 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/195 (2006.01) C07K 14/245 (2006.01) C07K 14/71 (2006.01) C07K 14/715 (2006.01) C07K 14/72 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2250567

Specific antagonists for prokaryotic or eukaryotic integral membrane proteins are provided. The antagonists are peptides having the amino acid sequence of a transmembrane domain of the integral membrane proteins or of a portion of analogue thereof. Methods are provided for preventing or treating disorders characterised by disordered function of an integral membrane protein by administration of a specific peptide antagonist of the integral membrane protein.

La présente invention concerne des antagonistes spécifiques de protéines intrinsèques procaryotes et eucaryotes. Lesdits antagonistes sont des peptides présentant la séquence d'acides aminés d'un domaine membranaire desdites protéines intrinsèques ou d'une portion ou d'un analogue de ces dernières. On décrit également des procédés permettant de prévenir ou de traiter des troubles caractérisés par des troubles fonctionnels d'une protéine intrinsèque en administrant un peptide antagoniste spécifique de la protéine intrinsèque.

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