A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/22 (2006.01) A61K 9/50 (2006.01) A61K 47/04 (2006.01) A61K 47/12 (2006.01) A61K 9/16 (2006.01)
Patent
CA 2475441
The present invention provides sustained-release preparations from which a pharmacologically active substance can be released over a long time and a process for producing the same. Such a sustained-release preparation is produced by melt-granulating a low-melting- point substance and a pharmacologically active substance and melt-coating the surface of the thus obtained particles with (1) a fine powder of a water-insoluble polymer or (2) a fine powder of a water-insoluble polymer and at least one member selected from the group consisting of talc, magnesium stearate and titanium oxide.
L'invention a pour objet de fournir des pr~parations ~ lib~ration lente ~ partir desquelles une substance pharmacologiquement active peut Útre lib~r~e sur une dur~e prolong~e. Elle concerne ~galement une m~thode de production desdites pr~parations. Une telle pr~paration ~ lib~ration lente est obtenue par granulation par fusion d'une substance se fondant ~ basse temp~rature et d'une substance pharmacologiquement active; et par enduction par fusion de la surface des grains ainsi obtenus avec: 1) une fine poudre d'un polymre insoluble dans l'eau, ou 2) une fine poudre d'un polymre insoluble dans l'eau dont un ~l~ment est s~lectionn~ dans le groupe constitu~ par st~arate de magn~sium et oxyde de titane.
Marks & Clerk
Otsuka Pharmaceutical Co. Ltd.
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