Tpp ii inhibitors for use in the treatment of autoimmune and...

A - Human Necessities – 61 – K

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A61K 38/00 (2006.01) A61K 38/06 (2006.01) A61P 1/04 (2006.01) A61P 3/10 (2006.01) A61P 9/10 (2006.01) A61P 17/00 (2006.01) A61P 19/02 (2006.01) A61P 25/28 (2006.01) A61P 27/02 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01) A61P 37/06 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2691415

TPP I1 (tripeptidyl peptidase II) inhibitors are useful in the treatment of autoimmune and/or inflammatory diseases, for example Systemic Lupus Erythematosus, Rheumatoid Arthritis, Multiple Sclerosis, Sjögrens Syndrome, Diabetes Mellitus Type I or II, Psoriasis, Eczema, Ulcerous Colitis and Chron's Disease, or transplant rejection. Suitable compounds comprise tripeptide compounds of general formula R N1 R N2N-A1-A2-A3-CO-R C1 wherein R N1, R N2, A1, A2, A3 and R C1 are as defined herein, and which include for example the tripeptide sequences GLA and GPG.

L'invention concerne des inhibiteurs de TPP Il (tripeptidyl peptidase II) utilisés dans le traitement de maladies auto-immunes et/ou inflammatoires, par exemple le lupus érythémateux systémique, la polyarthrite rhumatoïde, la sclérose en plaques, le syndrome de Sjögrens, le diabète mellitus de type I ou II, le psoriasis, l'eczéma, la colite ulcéreuse et la maladie de Crohn, ou un rejet de greffe. Les composés adaptés comprennent des composés tripeptidiques représentés par la formule générale RN1RN2N-A1-A2-A3-CO-RC1 dans laquelle RN1, RN2, A1, A2, A3 et RC1 sont tels que définis dans la description, et contenant, par exemple, les séquences tripeptidiques GLA et GPG.

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