C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/53 (2006.01) C12N 9/02 (2006.01) C12N 15/62 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2415344
Provided are methods and compositions useful in detecting protease activity in a sample, as well as methods of identifying agents that modulate protease activity. The methods and compositions provide a modified luciferase polynucleotide sequence and a luciferase polypeptide containing protease recognition sequences, wherein cleavage of the recognition sequence by a protease inhibits luciferase activity. Further provided are methods and compositions for detecting and modulating caspase activity and apoptosis.
L'invention concerne des procédés et compositions servant à détecter une activité protéase dans un échantillon, ainsi que des procédés d'identification d'agents modulant l'activité protéase. Lesdits procédés et compositions font intervenir une séquence de polynucléotides de luciférase modifiée et une séquence de reconnaissance de protéase contenant des polypeptides de luciférase, le clivage de la séquence de reconnaissance par une protéase inhibant l'activité luciférase. L'invention concerne par ailleurs des procédés et compositions servant à détecter et moduler l'activité caspase et l'apoptose.
Chemicon International Inc.
Mbm Intellectual Property Law Llp
LandOfFree
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