Mediators of hedgehog signaling pathways, compositions and...

Details Mediators of hedgehog signaling pathways, compositions and... Mediators of hedgehog signaling pathways, compositions and...

C - Chemistry, Metallurgy

07

D

C07D 239/91 (2006.01) A61K 31/517 (2006.01) A61P 35/00 (2006.01) C07D 239/36 (2006.01) C07D 401/12 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2385736

The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function by contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize hedgehog activity.

L'invention concerne des procédés et des réactifs pour inhiber des états de croissance aberrants résultant du gain de fonctionHedgehog, qui consistent à mettre la cellule en contact avec un antagoniste de hedgehog, telle qu'une petite molécule, en quantité suffisante par rapport à l'état de croissance aberrant, par exemple pour induire une réaction agoniste par rapport à une voie ptc normale ou une réaction antagoniste à l'activité de hedgehog.

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