Prophylaxis of allergic disease

Details Prophylaxis of allergic disease Prophylaxis of allergic disease

A - Human Necessities

61

K

A61K 39/35 (2006.01)

Patent

CA 2179170

The invention provides a method of prevention of allergic disease in an individual susceptible to such disease, comprising the step of administering to a previously unsensitised individual a dose and form of allergen effective to induce establishment of a stable population of allergen-specific T-helper-1-like memory lymphocytes, said lymphocytes being capable of inhibiting activity or amplification of allergen- specific T-helper-2-like lymphocytes responsible for stimulating production of IgE antibodies specific for said allergen. Compositions for use in the method of the invention are also disclosed and claimed.

La présente invention a pour objet une méthode de prévention des allergies destinée à un individu sujet à ce type de maladie. Ladite méthode consiste à administrer à un sujet préalablement insensibilisé une dose et une forme d'allergène suffisamment efficace pour induire l'établissement d'une population stable de lymphocytes à mémoire de type auxiliaire T1 spécifique de l'allergène, lesdits lymphocytes étant capables d'inhiber l'activité ou l'amplification de lymphocytes à mémoire de type auxiliaire T2 afin de stimuler la production d'anticorps IgE spécifiques dudit allergène. L'invention concerne également des compositions destinées à être utilisées dans ladite méthode.

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